Amir Husni, Bayu Pamungkas, Ellya Sinurat, Alim Isnansetyo

Abstract

Cancer is a disease that is considered a problem in the health sector. Cancer treatment methods still have side effects, so a safer alternative to anticancer treatment is needed. For example, fucoidan is a sulfated carbohydrate produced by brown seaweed and known to have a wide range of bioactivity, including anticancer activity. This study aimed to characterize fucoidan from the brown seaweed Sargassum hystrix and test its cytotoxic activity against the breast cancer cell line MCF-7. Fucoidan was extracted using distilled water at 85°C and characterized by determining the yield, total sugar, and total sulfate contents and analyzing its functional groups. Fucoidan was then subjected to a cytotoxic activity test on MCF-7 breast cancer cells based on an MTT method. Results demonstrated that S. hystrix fucoidan had a yield of 6.77% ± 1.47%, total sugar content of 69.35% ± 5.83%, and a sulfate content of 26.5% ± 2.73%. Functional group analysis revealed the existence of ester and sulfate in the extract, indicating the fucoidan content. Fucoidan elicited cytotoxic effects on MCF-7 breast cancer cells and had IC50 of 555.54 µg/mL. Fucoidan-exposed cancer cells shrank. They were round and had a limited spread pattern. Thus, S. hystrix fucoidan has an anticancer activity and should be further scrutinized as a potential alternative cancer therapy. read more

Amir Husni, Bayu Pamungkas, Ellya Sinurat, Alim Isnansetyo

Abstract

Cancer is a disease that is considered a problem in the health sector. Cancer treatment methods still have side effects, so a safer alternative to anticancer treatment is needed. For example, fucoidan is a sulfated carbohydrate produced by brown seaweed and known to have a wide range of bioactivity, including anticancer activity. This study aimed to characterize fucoidan from the brown seaweed Sargassum hystrix and test its cytotoxic activity against the breast cancer cell line MCF-7. Fucoidan was extracted using distilled water at 85°C and characterized by determining the yield, total sugar, and total sulfate contents and analyzing its functional groups. Fucoidan was then subjected to a cytotoxic activity test on MCF-7 breast cancer cells based on an MTT method. Results demonstrated that S. hystrix fucoidan had a yield of 6.77% ± 1.47%, total sugar content of 69.35% ± 5.83%, and a sulfate content of 26.5% ± 2.73%. Functional group analysis revealed the existence of ester and sulfate in the extract, indicating the fucoidan content. Fucoidan elicited cytotoxic effects on MCF-7 breast cancer cells and had IC50 of 555.54 µg/mL. Fucoidan-exposed cancer cells shrank. They were round and had a limited spread pattern. Thus, S. hystrix fucoidan has an anticancer activity and should be further scrutinized as a potential alternative cancer therapy. read more

The series of ASIIN (Die Akkreditierungsagentur für Studiengänge der Ingenieurwissenschaften, Informatik, Naturwissenschaften und Mathematik atau Accreditation Agency for Degree Programs in Engineering, Informatics/Computer Science, the Natural Sciences and Mathematics) accreditation activities has reached the final stage with online visitations. The visitation was held on March, 23-25 2021 attended by 7 assessors representatives from University, industry (practitioner), student, and ASIIN office. The on-line visitation was started by the meeting with UGM Rector, accompanied by the vice-rector, director, dean, vice-dean, and task force team. The visitation then continued with a discussion with the program coordinator. On the second and third day, the discussion was done with students, alumni, industries, and teaching staff. read more

The ASIIN accreditation online visitation will be held on March, 23-25 2021. For the best performance, all study programs (included BFPT) together with the Rector, Vice-rector, Director of University Quality Assurance office, Dean and vice-dean of the Faculty of Agriculture, dean and vice-dean of the Faculty of Forestry, University asset staff, and IT staff, held a final coordination meeting. We hope the accreditation process will run smoothly and BFPT is awarded a full 5-year ASIIN accreditation. read more

Dr. Amir and Dr. Sita published new book with tittle “Rumput Laut sebaga Sumber Pangan Kesehatan dan Kosmetik” or Seaweed as food, health and cosmetics source. Published on January 27, 2021.

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National Student Scientific Writing Competition (NARESCOM) was held by Semarang State University Research Unit on November 1, 2020 with theme “The Role of Millennial Generation in Optimizing Local Resources to Increase Productivity in the New Normal Era”. The competition consists of 2 stages, starting with full paper selection and question and answer presentation with the jury. The presentation stage was attended by 10 finalists from the Yogyakarta Syuhada Mosque Islamic College, Jakarta Stiami Institute, Muria Kudus University, Padjajaran University, Jambi University, Semarang University, Diponegoro University, Semarang State University, and Gadjah Mada Universiats. read more

Ayoo ramaikan ajang kompetisi nasional PKM 2021.

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Penyelesaian Kerja Lapangan Semester II tahun ajaran 2020/2021 selambat lambatnya pada  tanggal 5 Maret 2021